Calcium-activated chloride channels.

Calcium-activated chloride channels in the apical region of mouse vomeronasal sensory neurons

The rodent vomeronasal organ plays a crucial role in several social behaviors. Detection of pheromones or other emitted signaling molecules occurs in the dendritic microvilli of vomeronasal sensory neurons, where the binding of molecules to vomeronasal receptors leads to the influx of sodium and calcium ions mainly through the transient receptor potential canonical 2 (TRPC2) channel. To investi...

Calcium Activated Chloride Channels Can not Explain Forskolin-Stimulated Fluid Secretion in Pancreatic Ducts from Cystic Fibrosis Mice

The Journal of General Physiology Interactions between permeation and gating in the TMEM16B/anoctamin2 calcium-activated chloride channel

In the article, the reference Perez-Cornejo and Arreola (2004. Regulation of Ca2+-activated chloride channels by cAMP and CFTR in parotid acinar cells. Biochem. Biophys. Res. Commun. 316:612–617. http://dx.doi.org/10.1016/j.bbrc .2004.02.097) should not have been cited. The reference that should have been cited instead is Perez-Cornejo, P., J.A. De Santiago, and J. Arreola. 2004. Permeant anion...

A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity

TMEM16A forms calcium-activated chloride channels (CaCCs) that regulate physiological processes such as the secretions of airway epithelia and exocrine glands, the contraction of smooth muscles, and the excitability of neurons. Notwithstanding intense interest in the mechanism behind TMEM16A-CaCC calcium-dependent gating, comprehensive surveys to identify and characterize potential calcium sens...

Calcium-Activated Chloride Channels (CaCCs) Regulate Action Potential and Synaptic Response in Hippocampal Neurons

Central neurons respond to synaptic inputs from other neurons by generating synaptic potentials. Once the summated synaptic potentials reach threshold for action potential firing, the signal propagates leading to transmitter release at the synapse. The calcium influx accompanying such signaling opens calcium-activated ion channels for feedback regulation. Here, we report a mechanism for modulat...

Analysis of calcium activated chloride current fluctuations in Xenopus laevis oocytes.

Fluctuations of calcium activated chloride currents were investigated in oocytes of Xenopus laevis. The method of noise analysis and the model of chloride channels activation by calcium ions were used to estimate the chloride channels lifetime and the average frequency of current fluctuations, which depends on changes of cytoplasmic calcium concentration. This current fluctuations can be evoked...